Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin.

@article{Virus1979PharmacologicAO,
  title={Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin.},
  author={R. M. Virus and G. F. Gebhart},
  journal={Life sciences},
  year={1979},
  volume={25 15},
  pages={
          1273-83
        }
}
  • R. M. Virus, G. F. Gebhart
  • Published 1979
  • Medicine
  • Life sciences
  • Abstract The pharmacologic actions of capsaicin in the cardiovascular, respiratory, sensory, thermoregulatory, and gastrointestinal systems were reviewed as were the ultrastructural, neurophysiological, and neurochemical effects produced by this drug. Present evidence strongly suggests that substance P and serotonin are both involved in the pharmacological activity of capsaicin. Capsaicin apparently produces no direct effects on GABA-ergic, enkephalinergic or catecholaminergic systems. 
    140 Citations

    Topics from this paper

    Capsaicin and regulation of respiration: Interaction with central substance P mechanisms
    • 6
    Mechanism of capsaicin action: recent learnings.
    • 25

    References

    SHOWING 1-10 OF 21 REFERENCES
    Actions of substance P on sympathetic neurons
    • 139
    Capsaicin-evoked release of substance P from primary sensory neurons
    • 217