Pharmacologic Therapies in Patients With Exacerbation of Chronic Obstructive Pulmonary Disease

  title={Pharmacologic Therapies in Patients With Exacerbation of Chronic Obstructive Pulmonary Disease},
  author={Claudia Caroline Dobler and Allison S. Morrow and Bradley Beuschel and Magdoleen H. Farah and Abdul Mounaem Majzoub and Michael E. Wilson and Bashar Hasan and Mohamed Seisa and Lubna Daraz and Larry J. Prokop and Mohammad Hassan Murad and Zhen Wang},
  journal={Annals of Internal Medicine},
  pages={413 - 422}
Background Chronic obstructive pulmonary disease (COPD) is characterized by frequent exacerbations. Purpose To evaluate the comparative effectiveness and adverse events (AEs) of pharmacologic interventions for adults with exacerbation of COPD. Data Sources English-language searches of several bibliographic sources from database inception to 2 January 2019. Study Selection 68 randomized controlled trials that enrolled adults with exacerbation of COPD treated in out- or inpatient settings… Expand
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Role of acute exacerbations in skeletal muscle impairment in COPD
This report includes a review of both clinical and pre-clinical peer-reviewed literature of the past 20 years providing a comprehensive view on the role of AECOPD in muscle dysfunction in COPD, the putative underlying mechanisms and the treatment perspectives. Expand
LA inhalers for COPD: perceptions/reality of ABCD GOLD tool use
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WeChat as a Platform for Baduanjin Intervention in Patients With Stable Chronic Obstructive Pulmonary Disease in China: Retrospective Randomized Controlled Trial
The WeChat platform provided a feasible, effective, and sustainable management plan for Baduanjin rehabilitation and patients were very satisfied with the WeChat management because of the obvious curative effect and home feeling. Expand
Pharmacologic Management of COPD Exacerbations: A Clinical Practice Guideline from the AAFP.
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Inappropriate Antibiotic Prescribing for Respiratory Conditions Does Not Improve Press Ganey Patient Satisfaction Scores in the Emergency Department
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Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease.
Treatment of ambulatory exacerbations of mild-to-moderate COPD with amoxicillin/clavulanate is more effective and significantly prolongs the time to the next exacerbation compared with placebo. Expand
Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis.
A meta-analysis of randomized trials was performed to estimate the effectiveness of antibiotics in treating exacerbations of chronic obstructive pulmonary disease, suggesting a small but statistically significant improvement due to antibiotic therapy in patients with exacerbation of COPD. Expand
Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease.
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  • 1999
Treatment with systemic glucocorticoids results in moderate improvement in clinical outcomes among patients hospitalized for exacerbations of COPD, and the maximal benefit is obtained during the first two weeks of therapy. Expand
Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.
Doxycycline showed superiority in terms of clinical success and clinical cure on Day 10, microbiological success, the use of open label antibiotics, and symptoms, and there was no interaction between the treatment effect and any of the subgroup variables. Expand
Corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease
Systemic corticosteroids are efficacious in the treatment of A ECOPD and considered a standard of care for patients experiencing an AECOPD, and should be administered to all patients experiencing AECopD severe enough to seek emergent medical care. Expand
Management and prevention of exacerbations of COPD
  • S. Aaron
  • Medicine
  • BMJ : British Medical Journal
  • 2014
The addition of azithromycin to usual COPD therapy prevents exacerbations, although it may prolong the Q-T interval and increase the risk of death from cardiovascular disease in patients prone to arrhythmia. Expand
Antibiotics for exacerbations of chronic obstructive pulmonary disease.
This review shows that in COPD exacerbations with increased cough and sputum purulence antibiotics, regardless of choice, reduce the risk of short-term mortality by 77%, decrease the chance of treatment failure by 53% and therisk of sputuma purulence by 44%; with a small increase in the riskof diarrhoea. Expand
Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.
There was a significant benefit associated with antibiotic and Peak flow recovered more rapidly with antibiotic treatment than with placebo, and side effects were uncommon and did not differ between antibiotic and placebo. Expand
Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.
The evidence for a lower rate of relapse by one month for treatment with systemic corticosteroid in the treatment of people with acute exacerbations of COPD was graded as high quality and it would have been necessary to treat nine people with systemic Corticosteroids to avoid one treatment failure. Expand
Controlled trial of oral prednisone in outpatients with acute COPD exacerbation.
Outpatient treatment of acute COPD exacerbation with prednisone accelerates recovery of PaO2, A-aDO2, FEV1, and PEF, reduces the treatment failure rate, and improves subjective dyspnea. Expand