Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1
@article{Wainscott2007PharmacologicCO, title={Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1}, author={D. B. Wainscott and S. Little and T. Yin and Y. Tu and V. P. Rocco and J. X. He and D. Nelson}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2007}, volume={320}, pages={475 - 485} }
The hemagglutinin-tagged human trace amine-associated receptor1 (TAAR1) was stably coexpressed with rat Gαs in the AV12-664 cell line, and receptor activation was measured as the stimulation of cAMP formation. After blockade of endogenously expressed α2- and β-adrenoceptors with 2-[2-(2-methoxy-1,4-benzodioxanyl)]-imidazoline hydrochloride (2-methoxyidazoxan, RX821002) and alprenolol, respectively, the resulting pharmacology was consistent with that of a unique receptor subtype… CONTINUE READING
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