Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1

@article{Wainscott2007PharmacologicCO,
  title={Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1},
  author={D. B. Wainscott and S. Little and T. Yin and Y. Tu and V. P. Rocco and J. X. He and D. Nelson},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={320},
  pages={475 - 485}
}
  • D. B. Wainscott, S. Little, +4 authors D. Nelson
  • Published 2007
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • The hemagglutinin-tagged human trace amine-associated receptor1 (TAAR1) was stably coexpressed with rat Gαs in the AV12-664 cell line, and receptor activation was measured as the stimulation of cAMP formation. After blockade of endogenously expressed α2- and β-adrenoceptors with 2-[2-(2-methoxy-1,4-benzodioxanyl)]-imidazoline hydrochloride (2-methoxyidazoxan, RX821002) and alprenolol, respectively, the resulting pharmacology was consistent with that of a unique receptor subtype… CONTINUE READING
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