Pharmacologic Ascorbate in Myeloma Treatment: Doses Matter

  title={Pharmacologic Ascorbate in Myeloma Treatment: Doses Matter},
  author={Pierre-Christian Violet and Mark Levine},
Ascorbic acid (vitamin C) has followed opaque paths in treating pharmacologic ascorbate. Because myeloma cells are iron-rich, increasmultiplemyeloma, and othermalignancies. Inmyeloma cells, ascorbate surprisingly depleted glutathione and potentiated arsenate trioxide efficacy. Because oral ascorbate at 1 g produces plasma saturation, this dose was selected with arsenate. Predictably, in small trials there was neither benefit nor harm (Rollig and Illmer, 2009; Parrow et al., 2013). Concurrently… CONTINUE READING
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Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.

Proceedings of the National Academy of Sciences of the United States of America • 2008
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