Corpus ID: 198136081

Pharmacokinetics profile of serum and cellular Sofosbuvir along with its concentration effect analysis in HCV patients receiving Sofosbuvir and Ribavirin.

@article{Ahmed2019PharmacokineticsPO,
  title={Pharmacokinetics profile of serum and cellular Sofosbuvir along with its concentration effect analysis in HCV patients receiving Sofosbuvir and Ribavirin.},
  author={Bilal Ashfaq Ahmed and Bushra Munir and Abdul Ghaffar and Muhammad Arfat Yameen and Fatima Jalal and Muhammad Umar Farooq and Saba Shehzadi and Sara Ashraf and Ayesha Liaqat},
  journal={Pakistan journal of pharmaceutical sciences},
  year={2019},
  volume={32 3 (Supplementary)},
  pages={
          1269-1274
        }
}
Sofosbuvir along with ribavirin is being widely used for treatment of HCV in Pakistan but it may show delayed response and reoccurrence of disease in some cases. The aim of the study was to investigate pharmacokinetics and concentration effect analysis of sofosbuvir. HCV patients (n=100) received 400 mg sofosbuvir along with low dose or weight based ribavirin (400 mg). Nonlinear mixed effects modeling (NONMEM) and unpaired t-test were used for the association of concentrations and treatment… Expand