Pharmacokinetics ofl4C-2-allophanyl-2-allyl -gamma-valerolactone: a prodrug of proxibarbal in rats


The pharmacokinetics and metabolism of 2-allophanyl-2-allyl-gamma-valerolactone (AAV) was studied in rats. AAV was partially transformed to proxibarbal and urea, and its urinary elimination was very rapid. AAV becomes widely distributed in tissues and peak concentrations are reached rapidly. A dynamic equilibrium between AAV and proxibarbal was estalished… (More)
DOI: 10.1007/BF03189485

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