Pharmacokinetics of zimelidine

  title={Pharmacokinetics of zimelidine},
  author={Deidre Brown and David H. T. Scott and D. B. Scott and Mark Meyer and Douglas Westerlund and Jan Lundstr{\"o}m},
  journal={European Journal of Clinical Pharmacology},
The systemic availability of a new antidepressant, zimelidine, and of its pharmacologically active metabolite, norzimelidine, was studied in six healthy male volunteers. Three single doses of zimelidine (25 mg and 100 mg orally and 25 mg i.v.) and two single doses of norzimelidine (25 mg orally and i. v.) were given to each volunteer allowing at least seven days between administrations. Plasma concentrations of zimelidine and norzimelidine were determined in serial blood samples by HPLC… CONTINUE READING

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