Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate.
@article{Duconge2008PharmacokineticsOV, title={Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate.}, author={Jorge Duconge and Jorge R. Miranda-Massari and Michael J. Gonz{\'a}lez and James A. Jackson and William Warnock and Neil H Riordan}, journal={Puerto Rico health sciences journal}, year={2008}, volume={27 1}, pages={ 7-19 } }
There is a strong advocacy movement for large doses of vitamin C. Some authors argue that the biological half-life for vitamin C at high plasma levels is about 30 minutes, but these reports are the subject of some controversy. NIH researchers established the current RDA based upon tests conducted 12 hours (24 half lives) after consumption. The dynamic flow model refutes the current low-dose recommendations for dietary intakes and links Pauling's mega-dose suggestions with other reported effects…
108 Citations
Estimating the turnover time of high intravenous intake of vitamin C
- Medicine
- 2011
The application of first-order reaction kinetics has been shown to provide a means to estimate the depletion time at any intravenous high dosing of vitamin C.
Schedule Dependence in Cancer Therapy: Intravenous Vitamin C and the Systemic Saturation Hypothesis.
- MedicineJournal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine
- 2012
It is suggested that multiple, intermittent, short-term intravenous infusions of vitamin C over a longer time period will correlate with greater antitumor effects than do single continuous IV doses of the same total exposure.
A Rational Approach for Improving the Ascorbate Antineoplastic Activity
- MedicineCancer investigation
- 2014
Chen et al. deserved the merit to have clarified this problem and proposed that after intravenous administration of vitamin C, this compound, after transfer into the extravascular tissues, generates H2O2 and ascorbyl radicals, supporting Levine’s studies.
Preliminary Evidence That High-Dose Vitamin C has a Vascular Disrupting Action in Mice
- Biology, MedicineFront. Oncol.
- 2014
The results support the concept that vitamin C at high dose increases endothelial permeability, allowing platelets to escape and release serotonin, and Plasma 5-HIAA concentrations could provide a pharmacodynamic biomarker for vitamin C effects in clinical studies.
High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
- Biology, MedicineCancers
- 2021
The pharmacokinetic and pharmacodynamic properties of vitamin C are outlined to be taken into account in designing clinical studies that evaluate its potential use as anticancer agent.
The Cure from Nature: The Extraordinary Anticancer Properties of Ascorbate (Vitamin C)
- Medicine, Biology
- 2016
Vitamin C (sodium ascorbate) in high doses, administered by intravenous route, is safe, has minimal contraindications, improves the quality of life of patients, and is highly selective for cancer cells.
Vitamin C requirements in parenteral nutrition.
- MedicineGastroenterology
- 2009
On the basis of available pharmacokinetic data the 100 mg/d dose for patients receiving home PN and 200mg/d for stable adult patients receiving PN are adequate, but requirements have been shown to be higher in perioperative, trauma, burn, and critically ill patients, paralleling oxidative stress.
High-dose Therapy with Ascorbate, Niacin, Folate and B 12 : Pauling was Right but for the Wrong Reason
- Biology
- 2010
Responses to four vitamins advocated by Pauling can be best explained by the effects of these vitamins on lowering the nitric oxide (NO)/peroxynitrite (ONOO-) cycle, a possible generic mechanism for many chronic inflammatory diseases.
Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials
- MedicineAntioxidants
- 2018
Overall, vitamin C has been shown to be safe in nearly all patient populations, alone and in combination with chemotherapies, and the promising results support the need for randomized placebo- controlled trials such as the ongoing placebo-controlled trials of vitamin C and chemotherapy in prostate cancer.
Professional Resource: Intravenous Vitamin C (IVC)
- Medicine, Biology
- 2014
Intravenous infusion may raise serum levels of vitamin C 70-fold compared to those that may be achieved through oral dosing alone.
References
SHOWING 1-10 OF 62 REFERENCES
Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
- MedicineAnnals of Internal Medicine
- 2004
It is reported here that intravenous doses can produce plasma concentrations 30- to 70-fold higher than the maximum tolerated oral doses, and the role of vitamin C in cancer treatment should be reexamined, and insights from vitamin C pharmacokinetics can guide its clinical use.
Vitamin C Pharmacokinetics after Continuous Infusion in a Patient with Prostate Cancer
- MedicineThe Annals of pharmacotherapy
- 2007
The information obtained from this preliminary pharmacokinetic assessment of ascorbate at megadoses allows a better understanding of its disposition in cancer patients, and will help to optimize the dosage to be used in a perspective clinical trial in order to maximize the therapeutic benefits.
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance.
- MedicineProceedings of the National Academy of Sciences of the United States of America
- 1996
The current RDA of 60 mg daily should be increased to 200 mg daily, which can be obtained from fruits and vegetables, and safe doses of vitamin C are less than 1000mg daily, and vitamin C daily doses above 400 mg have no evident value.
Pharmacokinetic perspectives on megadoses of ascorbic acid.
- Medicine, BiologyThe American journal of clinical nutrition
- 1997
The analysis indicates that both saturable gastrointestinal absorption and nonlinear renal clearance act additively to produce the ceiling effect in plasma concentrations, and there is no pharmacokinetic justification for the use of megadoses of ascorbic acid.
A new recommended dietary allowance of vitamin C for healthy young women
- MedicineProceedings of the National Academy of Sciences of the United States of America
- 2001
Results of a depletion–repletion study with healthy young women hospitalized for 186 +/− 28 days, using vitamin C doses of 30–2,500 mg daily indicate that the Recommended Dietary Allowance for young women should be increased to 90 mg daily.
Effects of high dose ascorbate administration on L-10 tumor growth in guinea pigs.
- MedicinePuerto Rico health sciences journal
- 2005
Ascorbate concentrations sufficient to kill tumor cells can be safely achieved in solid tumors in vivo, suggesting a possible role for high dose intravenous ascorbates in treating cancer.
Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy.
- MedicineMedical hypotheses
- 1981
Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours
- Medicine, BiologyBritish Journal of Cancer
- 2001
The effect of ascorbate on doxorubicin efficacy was concentration dependent; low doses were protective while high doses increased cell killing, suggesting tumoricidal concentrations may be achievable in vivo.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2005
Human pharmacokinetics data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H(2)O(2), and that blood can be a delivery system of the pro- drug to tissues.