• Corpus ID: 545102

Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate.

  title={Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate.},
  author={Jorge Duconge and Jorge R. Miranda-Massari and Michael J. Gonz{\'a}lez and James A. Jackson and William Warnock and Neil H Riordan},
  journal={Puerto Rico health sciences journal},
  volume={27 1},
There is a strong advocacy movement for large doses of vitamin C. Some authors argue that the biological half-life for vitamin C at high plasma levels is about 30 minutes, but these reports are the subject of some controversy. NIH researchers established the current RDA based upon tests conducted 12 hours (24 half lives) after consumption. The dynamic flow model refutes the current low-dose recommendations for dietary intakes and links Pauling's mega-dose suggestions with other reported effects… 

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