Pharmacokinetics of verproside after intravenous and oral administration in rats

@article{Park2009PharmacokineticsOV,
  title={Pharmacokinetics of verproside after intravenous and oral administration in rats},
  author={Eun Jeong Park and Hyun Sook Lee and Sei-Ryang Oh and Hyeong-Kyu Lee and Hye Suk Lee},
  journal={Archives of Pharmacal Research},
  year={2009},
  volume={32},
  pages={559-564}
}
Verproside, a catalpol derivative iridoid glucoside isolated from Pseudolysimachion longifolium, is a candidate for anti-asthmatic drug. The dose-dependency of the pharmacokinetics of verproside was evaluated in rats after intravenous and oral administration. After intravenous administration of verproside (2, 5 and 10 mg/kg doses), the systemic clearance (Cl) was significantly reduced and AUC was significantly increased at 10 mg/kg dose compared to 2 and 5 mg/kg doses. The volume of… CONTINUE READING