Pharmacokinetics of verapamil and its metabolite norverapamil from a buccal drug formulation.

@article{Sawicki2002PharmacokineticsOV,
  title={Pharmacokinetics of verapamil and its metabolite norverapamil from a buccal drug formulation.},
  author={Wiesław Sawicki and S. Janicki},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={238 1-2},
  pages={181-9}
}
Pharmacokinetics of verapamil and its metabolite norverapamil, from buccal drug formulation administered in a dose 20 mg in relation to conventional tablets of verapamil 40 mg, used in medical practice, was determined. Buccal formulation has previously been designed as an alternative form of dosing verapamil. Bioavailability was determined by a crossover method in 12 healthy volunteers. Drug concentration in plasma was determined by means of HPLC with a fluorescence detector. For buccal… CONTINUE READING

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