Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain.

@article{Beaudry2009PharmacokineticsOV,
  title={Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain.},
  author={Francis Beaudry and Andr{\'e}anne Ross and Pablo Lema and Pascal Vachon},
  journal={Phytotherapy research : PTR},
  year={2009},
  volume={24 4},
  pages={
          525-30
        }
}
The analgesic effects of vanillin on neuropathic pain was evaluated using thermal sensitivity and mechanical allodynia using the sciatic nerve constriction model (n = 30 rats). To determine the pharmacokinetics of vanillin, rats (n = 6/administration route) received either 20 or 100 mg/kg of vanillin i.v. and p.o., respectively. For the pharmacodynamic study, baseline levels for hyperalgesia and allodynia were taken for 5 days prior to surgery. Following surgery each group (n = 6 rats/group… CONTINUE READING
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