Pharmacokinetics of trimethoprim-sulfamethoxazole in critically ill and non-critically ill AIDS patients.

@article{Chin1995PharmacokineticsOT,
  title={Pharmacokinetics of trimethoprim-sulfamethoxazole in critically ill and non-critically ill AIDS patients.},
  author={Thomas W F Chin and Art Vandenbroucke and Ignatius William Fong},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 1},
  pages={28-33}
}
Current dosage regimens of trimethoprim-sulfamethoxazole used to treat Pneumocystis carinii pneumonia in AIDS patients have been based on data from healthy subjects or patients without AIDS. The clearance and absorption characteristics of the drugs may potentially be different between patients with and without AIDS. This study was conducted to assess the pharmacokinetics of trimethoprim-sulfamethoxazole in critically ill and non-critically ill AIDS patients treated for P. carinii pneumonia… CONTINUE READING

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