Pharmacokinetics of triflusal and its main metabolite HTB in healthy subjects following a single oral dose

@article{Ramis1991PharmacokineticsOT,
  title={Pharmacokinetics of triflusal and its main metabolite HTB in healthy subjects following a single oral dose},
  author={Joaquim Ramis and R J Mis and Javier Forn and Josep Roca Torrent and Eduard Gorina and Francesc Jan{\'e}},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1991},
  volume={16},
  pages={269-273}
}
The pharmacokinetic profile of triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) and its main metabolite HTB (2-hydroxy-4-trifluoromethyl benzoic acid) has been studied in 8 healthy subjects (4 males and 4 females), after a single oral dose of 900 mg of triflusal. Plasma concentrations were determined by a sensitive HPLC method. Sampling was performed up to 120 h post medication. Triflusal displays a Cmax of 11.6±1.7 μg/ml and a tmax of 0.88±0.26 h. The elimination half-life (t1/2) was 0.55… CONTINUE READING

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