Corpus ID: 44972057

Pharmacokinetics of triclosan in rat after intravenous and intravaginal administration.

@article{Siddiqui1979PharmacokineticsOT,
  title={Pharmacokinetics of triclosan in rat after intravenous and intravaginal administration.},
  author={W. H. Siddiqui and H. Buttar},
  journal={Journal of environmental pathology and toxicology},
  year={1979},
  volume={2 3},
  pages={
          861-71
        }
}
The pharmacokinetics of triclosan was studied in sexually mature virgin Wistar rats. 14C-triclosan was injected either via the femoral vein, (iv, 5 mg/kg in polyethylene glycol-400) or into the vaginal orifice (ivg, 5 mg/kg in corn oil). Radioactivity was determined by liquid scintillation spectrophotometry. After iv administration, the dissapearance of 14C from the blood followed the kinetics of a two-compartment open-system model. The apparent volume of distribution was 42 percent of the body… Expand
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