Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats.

@article{Devane1999PharmacokineticsOT,
  title={Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats.},
  author={C Lindsay Devane and David Boulton and Lisa Friedman Miller and Ronald L. Miller},
  journal={The international journal of neuropsychopharmacology},
  year={1999},
  volume={2 1},
  pages={17-23}
}
Sprague-Dawley rats were used as models for single trazodone administration (males), continuous adminstration and dose proportionality experiments (males, females, pregnant females). Plasma and brain tissue were analysed for trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP). Fetal exposure to trazodone and m-CPP was assessed and differences in their steady-state plasma concentration were sought between adult males and females. Both trazodone and m-CPP rapidly appeared in… CONTINUE READING

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