Pharmacokinetics of topical beta-adrenergic antagonists in rabbit aqueous humor evaluated with the microdialysis method.

@article{Ohtori1998PharmacokineticsOT,
  title={Pharmacokinetics of topical beta-adrenergic antagonists in rabbit aqueous humor evaluated with the microdialysis method.},
  author={R Ohtori and Hitomi Sato and Shuichi Fukuda and Tadahiko Ueda and Ryohei Koide and Yoshinobu Kanda and Yoshiaki Kiuchi and Katsuji Oguchi},
  journal={Experimental eye research},
  year={1998},
  volume={66 4},
  pages={487-94}
}
The microdialysis method was used to evaluate the pharmacokinetics of the beta-adrenergic antagonists carteolol and timolol and the new ophthalmic solution WP-934 in rabbit aqueous humor, following instillation. A probe with a microdialysis membrane (length, 5 mm; diameter, 0.2 mm) was implanted in the anterior chamber of the pigmented rabbit and perfused with Ringer's solution. Twenty microliters of 0.5% timolol maleate (0.5% Timoptol(R)), 2% carteolol hydrochloride (2% Mikelan(R)), or a novel… CONTINUE READING

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