Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs.

@article{Lim2010PharmacokineticsOT,
  title={Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs.},
  author={Jong-Hwan Lim and M. Kim and Y. Hwang and In-Bae Song and B. Park and H. Yun},
  journal={The Journal of veterinary medical science},
  year={2010},
  volume={72 8},
  pages={
          1085-7
        }
}
  • Jong-Hwan Lim, M. Kim, +3 authors H. Yun
  • Published 2010
  • Chemistry, Medicine
  • The Journal of veterinary medical science
  • Toltrazuril (TZR) is a triazine-based antiprotozoal agent. Following a single oral administration of TZR at 10 and 20 mg/kg to male pigs, the mean TZR concentration in plasma peaked at 4.24 and 8.18 microg/ml at 15.0 and 12.0 hr post-dose, respectively. TZR absorbed was rapidly converted to the short-lived intermediary metabolite toltrazuril sulfoxide (TZR-SO), and then metabolized to the reactive toltrazuril sulfone (TZR-SO2). TZR-SO2 was actually more slowly eliminated, with average half… CONTINUE READING
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