Pharmacokinetics of tolfenamic acid in patients with cirrhosis of the liver


Six patients with alcoholic cirrhosis of the liver received 100 mg tolfenamic acid p.o. and i.v. The disposition of tolfenamic acid could be described by a two-compartment open body model, with a mean central compartment volume of 8.71, and a β-phase volume of 251. The elimination rate constant ke averaged 1.13 h−1 and the half-life of the β-phase was 1.73… (More)
DOI: 10.1007/BF00544069


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