Pharmacokinetics of tolbutamide in ethnic Chinese.

@article{Gross1999PharmacokineticsOT,
  title={Pharmacokinetics of tolbutamide in ethnic Chinese.},
  author={Annette S. Gross and Simone Bridge and Gillian M. Shenfield},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={47 2},
  pages={
          151-6
        }
}
AIMS Ethnic differences in drug disposition have been described for many drugs. Despite the widespread use of tolbutamide in Asian populations, the pharmacokinetics of tolbutamide, a CYP2C9 substrate, have not been described in ethnic Chinese. METHODS The pharmacokinetics of tolbutamide (500 mg orally) were studied in 10 young, healthy volunteers (seven male/three female; age 21-29 years), each of whom had four ethnic Chinese grandparents. Plasma concentrations of tolbutamide were measured… CONTINUE READING

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