Pharmacokinetics of tocainide in patients with combined hepatic and renal dysfunction

  title={Pharmacokinetics of tocainide in patients with combined hepatic and renal dysfunction},
  author={Dirk Oltmanns and Anthony Pottage and W. Endell},
  journal={European Journal of Clinical Pharmacology},
The disposition of tocainide following an i.v. infusion of tocainide HCl 100 mg was studied in 6 patients with decompensated cirrhosis (ascites) and renal dysfunction. In one patient with active hepatic necrosis the terminal plasma half-life was 57.4, and in the others the half life ranged from 16.0 to 29.0 h. The increase in half-life was correlated with biochemical evidence of renal dysfunction, but not with individual tests of hepatic function. Non-renal clearance of tocainide was similar to… CONTINUE READING


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