Pharmacokinetics of tocainide in patients with combined hepatic and renal dysfunction

@article{Oltmanns1983PharmacokineticsOT,
  title={Pharmacokinetics of tocainide in patients with combined hepatic and renal dysfunction},
  author={Dirk Oltmanns and Anthony Pottage and W. Endell},
  journal={European Journal of Clinical Pharmacology},
  year={1983},
  volume={25},
  pages={787-790}
}
The disposition of tocainide following an i.v. infusion of tocainide HCl 100 mg was studied in 6 patients with decompensated cirrhosis (ascites) and renal dysfunction. In one patient with active hepatic necrosis the terminal plasma half-life was 57.4, and in the others the half life ranged from 16.0 to 29.0 h. The increase in half-life was correlated with biochemical evidence of renal dysfunction, but not with individual tests of hepatic function. Non-renal clearance of tocainide was similar to… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-7 of 7 references

Pbarmacokinetics of metoprolol in patients with hepatic cirrhosis

  • CG Reggrdh, L JordO, M Ervik, P Lundborg, R Olsson, O Ronn
  • Clin Pbarmacokinet
  • 1981

Pharmacokinetics of tocainide following intravenous and oral administration in healthy subjects and in patients with acute myocardial infarction

  • C Graffner, T-B Conradson, S Hofvendahl, L Rydgm
  • Clin Phannacol Ther
  • 1980
2 Excerpts

Similar Papers

Loading similar papers…