Pharmacokinetics of thiopental after single and multiple intravenous doses in critical care patients

@article{Russo2004PharmacokineticsOT,
  title={Pharmacokinetics of thiopental after single and multiple intravenous doses in critical care patients},
  author={H{\'e}l{\`e}ne Russo and Janine Br{\`e}s and M P Duboin and B. Roquefeuil},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={49},
  pages={127-137}
}
Thiopental was administered to neurosurgical patients for cerebral protection and its pharmacokinetic parameters were determined after a single bolus of 540, 1000 or 1500 mg (3 subjects) or after multiple doses of 250 mg (5 subjects) and 500 mg (2 subjects) every two hours for up to 7 days. The data were analysed by a two- or three- compartment model and linear kinetics. After a single IV bolus, the mean initial volume of distribution (V1) was 0.4811·kg−1, and the steady-state volume of… 
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