Pharmacokinetics of thiamine derivatives especially of benfotiamine.

  title={Pharmacokinetics of thiamine derivatives especially of benfotiamine.},
  author={Daniela Loew},
  journal={International journal of clinical pharmacology and therapeutics},
  volume={34 2},
  • Daniela Loew
  • Published 1996 in
    International journal of clinical pharmacology…
Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only… CONTINUE READING

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