Corpus ID: 37618041

Pharmacokinetics of thiamine derivatives especially of benfotiamine.

@article{Loew1996PharmacokineticsOT,
  title={Pharmacokinetics of thiamine derivatives especially of benfotiamine.},
  author={Dieter Loew},
  journal={International journal of clinical pharmacology and therapeutics},
  year={1996},
  volume={34 2},
  pages={
          47-50
        }
}
  • D. Loew
  • Published 1 February 1996
  • Chemistry, Medicine
  • International journal of clinical pharmacology and therapeutics
Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only… Expand
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