Corpus ID: 37618041

Pharmacokinetics of thiamine derivatives especially of benfotiamine.

  title={Pharmacokinetics of thiamine derivatives especially of benfotiamine.},
  author={Dieter Loew},
  journal={International journal of clinical pharmacology and therapeutics},
  volume={34 2},
  • D. Loew
  • Published 1 February 1996
  • Chemistry, Medicine
  • International journal of clinical pharmacology and therapeutics
Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only… Expand
Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride
The results showed that thiamine and its phosphorylated metabolites exhibited different pharmacokinetic characteristics in plasma, blood and erythrocyte, and one‐compartment model provided the best fit for pharmacokinetics profiles of thiamines. Expand
Comparative Pharmacokinetic Analysis of Thiamine and Its Phosphorylated Metabolites Administered as Multivitamin Preparations.
Findings support clear benefits of lipophilic thiamine derivatives in the absorption ofThiamine in healthy volunteers and support the conventional bioequivalence range. Expand
Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should be differentiated from truly lipid-soluble thiamine disulfide derivatives with a different mechanism of absorption and different pharmacological properties, which would explain why beneficial effects of benfutiamine have only been observed in peripheral tissues. Expand
High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfotiamine
The pharmacokinetics of TDP in blood were compared with healthy subjects of other studies retrieved from database query, and the patients with ESRD had a 4.3 times higher area under the concentration–time curve after benfotiamine administration than after thiamine nitrate. Expand
Benfotiamine. Monograph.
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
  • 2006
In addition to diabetic neuropathy, benfotiamine appears to be of value in treating diabetic retinopathy and nephropathy, and has also been shown to have beneficial effects in patients with end-stage renal disease and alcoholic neuropathy. Expand
Pharmacokinetics of the transdermal delivery of benfotiamine
This strong increase in the tissue levels of T and the associated metabolic derivatives levels found in the blood and local tissues following a single dose indicate that topically applied BFT may be a viable and advantageous delivery method for the treatment of diabetic peripheral neuropathy. Expand
Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine
In vitro studies show that another thiamine thioester, dibenzoylthiamine (DBT) is even more efficient that BFT, especially with respect to its anti-inflammatory potency. Expand
Prodrug thiamine analogs as inhibitors of the enzyme transketolase.
An efficient way of improving the pharmacokinetic profile of 5a is to prepare oxidized prodrugs which are slowly reduced in vivo yielding longer, sustained blood levels of the drug. Expand
Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs
This chapter provides the rationale for the use of prodrugs along with selective examples ofProdrugs used to effect improved oral delivery of poorly permeable drugs. Expand
The multifaceted therapeutic potential of benfotiamine.
The present review critically analyzed the multifaceted therapeutic potential of benfotiamine and found it effective for the treatment of diabetic neuropathy, nephropathy and retinopathy. Expand