Pharmacokinetics of theophylline in children with asthma.

@article{Ellis1976PharmacokineticsOT,
  title={Pharmacokinetics of theophylline in children with asthma.},
  author={EvelynF. Ellis and R Koysooko and Gerhard Levy},
  journal={Pediatrics},
  year={1976},
  volume={58 4},
  pages={
          542-7
        }
}
The pharmacokinetics of theophylline following intravenous injection of aminophylline, 4 mg/kg of body weight, were determined in 30 children with asthma and in 6 normal adult volunteers. The average total clearance of theophylline was 87 ml/hr/kg in the children and 57 ml/hr/kg in the adults. The biologic half-life of theophylline in the children ranged from 1.42 to 7.85 hours, reflecting mainly pronounced interindividual differences in the elimination rate constant of the drug. There was no… CONTINUE READING

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