Pharmacokinetics of theophylline and its metabolites in rabbits

Abstract

The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the… (More)
DOI: 10.1007/BF03189755

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