Pharmacokinetics of the third-generation cephalosporins.

The pharmacokinetics of 10 of the newer, third-generation cephalosporins are reviewed. Important features are tabulated. Generalizations are made about structure-activity relationships, relationships between kinetic features, minimal inhibitory concentrations, dosage regimens, and tissue penetration. Tissue levels of ceftazidime are given as examples. These… CONTINUE READING