Pharmacokinetics of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects.

@article{Sakashita1993PharmacokineticsOT,
  title={Pharmacokinetics of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects.},
  author={Motokazu Sakashita and Tatsuya Yamaguchi and Hiroyuki Miyazaki and Yokio Sekine and Tetsuo Nomiyama and Satoru Tanaka and Takashi Miwa and Shigeru Harasawa},
  journal={Arzneimittel-Forschung},
  year={1993},
  volume={43 8},
  pages={867-72}
}
The pharmacokinetics and dose proportionality of mosapride citrate ((+-)-4-amino-5-chloro-2-ethoxy-N-[[4- (4-fluorobenzyl)-2-morpholinyl]methyl]benzamide citrate dihydrate, AS-4370, CAS 112885-42-4) were investigated in healthy male volunteers. The subjects were given a single oral dose (5, 10, 20 and 40 mg, each of 5 subjects) and a multiple oral dose (20 mg t.i.d. for one day, and 10 and 20 mg t.i.d. for 8 days, each of 5 subjects). Food effect on the pharmacokinetics of mosapride was also… CONTINUE READING

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