Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans

  title={Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans},
  author={Peter H. Hinderling and Edward R. Garrett},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
The pharmacokinetics of the antiarrhythmic disopyramide, 4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide phosphate, and its monodealkylated metabolite were investigated in seven volunteers after intravenous (1 and 2 mg/kg) and oral (3 and 6 mg/kg) administration. Unchanged drug (52%) and the monodealkylated metabolite (25%) were renally excreted on intravenous administration. The pharmacokinetics of disopyramide were first order and dose independent only when referenced to the drug not… CONTINUE READING