Pharmacokinetics of the adrenocorticolytic compounds 3-methylsulphonyl-DDE and o,p′-DDD (mitotane) in Minipigs

@article{Hermansson2007PharmacokineticsOT,
  title={Pharmacokinetics of the adrenocorticolytic compounds 3-methylsulphonyl-DDE and o,p′-DDD (mitotane) in Minipigs},
  author={Veronica Hermansson and Tatiana Cantillana and Lotta Hovander and {\AA}ke Lennart Bergman and Karl Ljungvall and Ulf Magnusson and Karolina T{\"o}rneke and I. Brandt},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2007},
  volume={61},
  pages={267-274}
}
The pharmacokinetics of the adrenocorticolytic drug candidate 3-Methylsulphonyl-DDE (3-MeSO2-DDE) and the anticancer drug o,p′-DDD (mitotane) were studied in Göttingen minipigs. The animals were given 3-MeSO2-DDE or o,p′-DDD as single oral doses (30 mg/kg). Concentrations in plasma and subcutaneous fat were measured by gas chromatography at different time points during 180 days. Maximal plasma concentrations appeared within 24 h for both compounds, but were about 2 times higher for 3-MeSO2-DDE… CONTINUE READING