Pharmacokinetics of the R(-) and S(+) enantiomers of ibuprofen in the serum and synovial fluid of arthritis patients.

@article{Cox1991PharmacokineticsOT,
  title={Pharmacokinetics of the R(-) and S(+) enantiomers of ibuprofen in the serum and synovial fluid of arthritis patients.},
  author={Steve R. Cox and Eric P. Gall and Kelly Forbes and M. S. Gresham and George Goris},
  journal={Journal of clinical pharmacology},
  year={1991},
  volume={31 1},
  pages={
          88-94
        }
}
Eight patients with arthritis and knee effusions received 13 doses of a single 800-mg ibuprofen tablet every 8 hours. Serum and synovial fluid samples were obtained after the first and last doses and assayed for the R(-) and S(+) enantiomers of ibuprofen by a stereospecific assay. Since only S(+)-ibuprofen inhibits cyclo-oxygenase, a description of the time course of this isomer in synovial fluid is needed for the development of suitable pharmacodynamic models. The isomers were significantly… CONTINUE READING

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