Pharmacokinetics of temocapril and enalapril in patients with various degrees of renal insufficiency.

@article{Oguchi1993PharmacokineticsOT,
  title={Pharmacokinetics of temocapril and enalapril in patients with various degrees of renal insufficiency.},
  author={Haruhisa Oguchi and Muneo Miyasaka and Toshihiko Koiwai and Shiho Tokunaga and Karel Hora and Kozo Sato and Tadamasa Yoshie and Hisashi Shioya and Seiichi Furuta},
  journal={Clinical pharmacokinetics},
  year={1993},
  volume={24 5},
  pages={421-7}
}
Temocapril is a novel ACE inhibitor that is cleared via dual excretion routes in humans. Borderline or mildly hypertensive patients with normal renal function [group 1, creatinine clearance (CLCR) > 70 ml/min (4.2 L/h), n = 12], moderate renal impairment [group 2, CLCR 30 to 70 ml/min (1.8 to 4.2 L/h), n = 12] or severe renal impairment [group 3, CLCR < 30 ml/min (1.8 L/h), n = 12] received a single oral dose of either temocapril 1 mg (n = 6, each group) or enalapril 5mg (n = 6, each group… CONTINUE READING
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