Pharmacokinetics of temazepam after day-time and night-time oral administration

  title={Pharmacokinetics of temazepam after day-time and night-time oral administration},
  author={F. Otto M{\"u}ller and Madel{\'e} Dyk and Hans K. L. Hundt and Anton Joubert and Herman G. Luus and Gerhard Groenewoud and G. C. Dunbar},
  journal={European Journal of Clinical Pharmacology},
SummaryThe pharmacokinetic disposition of temazepam was compared after a day-time and night-time dose in an open randomised crossover study. Twelve healthy male volunteers received a single oral dose of 20 mg temazepam in a soft gelatine capsule at 0900 h or 2200 h. Blood samples were taken immediately before dosing and at selected times over the 36-h period after each dose.The absorption of temazepam was slower after evening administration; the absorption half-life and time to reach maximal… 
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