Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifen-hydroxybutenyl-beta-cyclodextrin formulations.

@article{Buchanan2007PharmacokineticsOT,
  title={Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifen-hydroxybutenyl-beta-cyclodextrin formulations.},
  author={Charles Michael Buchanan and Norma Lindsey Buchanan and Kevin J Edgar and James L. Little and Michael Orlando Malcolm and Karen M Ruble and Vincent J. Wacher and Michael F. Wempe},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 3},
  pages={
          644-60
        }
}
Oral and intravenous administration of tamoxifen base and tamoxifen citrate formulated with hydroxybutenyl-beta-cyclodextrin (HBenBCD) to Sprague-Dawley rats significantly increased the oral bioavailability of tamoxifen relative to that of parent drug (no HBenBCD). When formulated with HBenBCD, the form of tamoxifen (base vs. salt) made no difference in the oral bioavailability of tamoxifen. Liquid formulations (PG:PEG400:H2O) provided higher oral bioavailability than solid formulations… CONTINUE READING

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