Pharmacokinetics of sustained release theophylline in low and high multidose regimens.

  title={Pharmacokinetics of sustained release theophylline in low and high multidose regimens.},
  author={Gerard H. Ko{\"e}ter and J. H. G. Jonkman and Koert de Vries and R T Schoenmaker and Jan E. Greving and Rokus A de Zeeuw},
  journal={British journal of clinical pharmacology},
  volume={12 5},
1 The in vitro characteristics (dissolution rate) of a sustained release theophylline preparation (Theo-Dur were first measured in acid medium (pH = 1) for 2 h and after that in a phosphate buffer (pH = 6.8) for 6 h. 2 The tablets released more than 95% of the active ingredient within 5 h at a rate of approximately 11% of the dose per hour at pH = 1 and about 18% at pH = 6.8. 3 Dose dependency of the pharmacokinetics of theophylline was tested in seven healthy volunteers by giving them either… CONTINUE READING


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