Pharmacokinetics of sulphadimethoxine in channel catfish (Ictalurus punctatus).

  title={Pharmacokinetics of sulphadimethoxine in channel catfish (Ictalurus punctatus).},
  author={C M Michel and Katherine S. Squibb and J M O'connor},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={20 12},
1. Plasma clearance, bioavailability, tissue disposition and elimination of 14C-sulphadimethoxine (SDM) were studied in channel catfish (Ictalurus punctatus) after intravenous (i.v.) and oral dosing (per os; p.o.) at 40 mg/kg body weight. 2. Analysis of blood SDM concentrations over time for intravascularly administered SDM showed that disposition and elimination were best described by a two-compartment pharmacokinetic model; estimated half-lives for SDM in blood were 0.09 and 12.6 h for the… CONTINUE READING