Pharmacokinetics of sufentanil in normal children

@article{Guay1992PharmacokineticsOS,
  title={Pharmacokinetics of sufentanil in normal children},
  author={Joanne Guay and Pierre Gaudreault and Ada Tang and Bernard N Goulet and France Varin},
  journal={Canadian Journal of Anaesthesia},
  year={1992},
  volume={39},
  pages={14-20}
}
The pharmacokinetic variables of sufentanil were studied in 20 healthy children between two and eight years of age. The plasma concentrations of sufentanil were measured for up to 480 min after administration of a bolus of sufentanil, 1–3 μg · kg−1. The distribution half-life (t1/2β) was 5.2 ±2.2 (mean ±SD) min and the elimination half life (t1/2β) was 97.0 ±42.0 min. The volume of distribution at steady state (Vdss) was 2.9 ±0.6 L · kg−1 and the clearance was 30.5 ±8.8 ml · kg−1 · min−1. The… CONTINUE READING

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