Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat.

  title={Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat.},
  author={Michael C. Kohn and Ronald L. Melnick and Frank Ye and Christopher J. Portier},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={30 6},
A biologically based mathematical model was created to characterize time and dose-dependent relationships between exposure to nitrite and induction of methemoglobinemia. The model includes mass action equations for processes known to occur: oral absorption of nitrite, elimination from the plasma, partitioning between plasma and erythrocytes, binding of nitrite to hemoglobin and methemoglobin, and the free radical chain reaction for hemoglobin oxidation. The model also includes Michaelis-Menten… CONTINUE READING


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Transport and Diffusion across Cell Membranes, pp 427

  • WD Stein, WR Lieb
  • 1986
Highly Influential
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