Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices

@article{Yez2008PharmacokineticsOS,
  title={Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices},
  author={Jaime A. Y{\'a}{\~n}ez and Connie M. Remsberg and Nicole D. Miranda and Karina R. Vega-Villa and Preston K. Andrews and Neal M. Davies},
  journal={Biopharmaceutics \& Drug Disposition},
  year={2008},
  volume={29}
}
The majority of pharmacokinetic studies of individual flavonoids or after ingestion of foodstuffs have overlooked the chirality of some of these xenobiotics. In order to characterize for the first time the stereoselective pharmacokinetics of three flavonoids, hesperetin, naringenin and eriodictyol were intravenously administered (20 mg/kg) to male Sprague‐Dawley rats, and their stereospecific content was assessed in various fruit juices. Concentrations in serum, urine and fruit juices were… 
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