Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices

  title={Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices},
  author={Jaime A. Y{\'a}{\~n}ez and Connie M. Remsberg and Nicole D. Miranda and Karina R. Vega-Villa and Preston K. Andrews and Neal M. Davies},
  journal={Biopharmaceutics \& Drug Disposition},
The majority of pharmacokinetic studies of individual flavonoids or after ingestion of foodstuffs have overlooked the chirality of some of these xenobiotics. In order to characterize for the first time the stereoselective pharmacokinetics of three flavonoids, hesperetin, naringenin and eriodictyol were intravenously administered (20 mg/kg) to male Sprague‐Dawley rats, and their stereospecific content was assessed in various fruit juices. Concentrations in serum, urine and fruit juices were… 
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The results revealed that naringin underwent extensive phase II metabolism in the human body and yielded an array of conjugated products, including conjugative metabolites and five polyphenols.
Stereospecific pharmacokinetics of racemic homoeriodictyol, isosakuranetin, and taxifolin in rats and their disposition in fruit.
The pharmacokinetics of homoeriodictyol, isosakuranetin, and taxifolin revealed distribution, metabolism, and elimination that were dependent on the stereochemistry of the stereoisomers.
Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin
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Comparative protein binding of naringin and its aglycone naringenin in rat, dog and human plasma
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Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
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Hesperidin and naringenin
A stereospecific HPLC method and its application in determination of pharmacokinetics profile of two enantiomers of naringenin in rats.
A stereospecific HPLC method that could separate two enantiomers (R/S epimer) of naringenin in bottom base has been developed and validated, and then further applied it to determine stereoselective pharmacokinetics of nareden in rats, and the results showed that the method was reliable.
Stereospecific high-performance liquid chromatography of taxifolin, applications in pharmacokinetics, and determination in tu fu ling (Rhizoma smilacis glabrae) and apple (Malus x domestica).
A stereospecific method of analysis of racemic taxifolin (+/-3,5,7,3',4'-pentahydroxyflavanone) in biological fluids is necessary to study pharmacokinetics and disposition in fruit and herbs. A


Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
In case of a moderate or high consumption of orange juice, flavanones may represent an important part of the pool of total polyphenols present in plasma.
Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
Oral administration of the flavanone aglycones, hesperetin and naringenin, lead to their rapid absorption as their conjugated forms, and cumulative urinary recovery data indicated low bioavailability for both flavanones.
Food effects on the absorption and pharmacokinetics of cocoa flavanols.
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It is concluded that because of the relatively high concentrations of flavanones in plasma after ingestion of orange juice or grapefruit juice, considerable health effects could ensue in individuals consuming them regularly.
Interactions of the flavonoid naringenin in the gastrointestinal tract and the influence of glycosylation.
The urinary recoveries of the flavonoid naringenin-7-glucoside and its aglycone and the lack of detection of glucuronide after intravenous administration suggest that the glycoside group is cleaved by an intestinal enzyme prior to glucuronidation within the epithelium.
Pharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in rats
The pharmacokinetics of piceatannol, pinosylvin and rhapontigenin were characterized in male Sprague‐Dawley rats after single intravenous doses of each stilbene and the estimates of oral bioavailability characterize these stilbenes as poorly bioavailable compounds.
Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.
The present study is the first report elucidating the chemical structures and changes in individual concentrations in rat plasma of glucuronides derived from orally administered hesperidin.
Naringenin from cooked tomato paste is bioavailable in men.
This is the first study demonstrating naringenin bioavailability in humans after consumption of a meal containing cooked tomato paste and rutin and chlorogenic acid in tomato paste were not detected in plasma at any time.
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
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