Pharmacokinetics of ritonavir and nevirapine in peritoneal dialysis.

  title={Pharmacokinetics of ritonavir and nevirapine in peritoneal dialysis.},
  author={Hassane Izzedine and Vincent Launay-Vacher and Gilbert Deray},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={16 3},
Sir, Hepatic clearance is the major route of elimination of ritonavir and nevirapine (-95% and 85%, respectively). Therefore it has been suggested that no dosage adjustment is necessary in patients with renal insuf®ciency w1,2x. However , no study is available on the in¯uence of continuous ambulatory peritoneal dialysis (CAPD) on the pharmaco-kinetics of ritonavir. We report on the pharmacokinetics of ritonavir and nevirapine in an HIV-1 patient on CAPD. Case. A 40-year-old man with end-stage… CONTINUE READING