Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects

  title={Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects},
  author={Christian Lacroix and T. Phan Hoang and Jenna Nouveau and C D Guyonnaud and G{\'e}rard Laine and H. Duwoos and Olivier Lafont},
  journal={European Journal of Clinical Pharmacology},
The plasma and urine pharmacokinetic parameters of pyrazinamide and of its metabolites (pyrazinoic acid, 5-hydroxy-pyrazinamide, 5-hydroxy-pyrazinoic acid and pyrazinuric acid) have been studied after a single oral dose of pyrazinamide 27 mg · kg−1 in 9 healthy subjects. Pyrazinamide was rapidly absorbed (tmax ≤1 h) and showed a short distribution phase followed by an elimination phase of t1/2β=9.6 h. The close similarity of the apparent elimination rates of the metabolites led to a second… CONTINUE READING

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