Pharmacokinetics of propofol infusions in patients with cirrhosis.

  title={Pharmacokinetics of propofol infusions in patients with cirrhosis.},
  author={Fr{\'e}d{\'e}rique S Servin and Ian D Cockshott and Robert Farinotti and J. P. Haberer and Camila Winckler and Jean Marie Desmonts},
  journal={British journal of anaesthesia},
  volume={65 2},
We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1. After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1. The mean recovery time after discontinuation of the infusion was significantly longer in the cirrhotic group; however, when patients opened their eyes, blood concentrations… CONTINUE READING