Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients


INTRODUCTION Only limited information exists on the pharmacokinetics of prolonged (> 24 hours) and high-dose dexmedetomidine infusions in critically ill patients. The aim of this study was to characterize the pharmacokinetics of long dexmedetomidine infusions and to assess the dose linearity of high doses. Additionally, we wanted to quantify for the first… (More)
DOI: 10.1186/cc10518


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