Pharmacokinetics of primaquine in patients withP. Vivax malaria

  title={Pharmacokinetics of primaquine in patients withP. Vivax malaria},
  author={S. Bhatia and Y. S. Saraph and S. Revankar and K. Doshi and E. D. Bharucha and N. Desai and A. Vaidya and D. Subrahmanyam and K. Gupta and R. Satoskar},
  journal={European Journal of Clinical Pharmacology},
  • S. Bhatia, Y. S. Saraph, +7 authors R. Satoskar
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
  • SummaryThe pharmacokinetics of primaquine (PQ) and its major carboxylic acid metabolite (PQC) have been studied in seven Indian patients withP. vivax malaria following PQ 15 mg/day p.o. for 14 days. After a single oral dose on Day 1, a mean peak blood concentration of 50.7 ng/ml PQ was attained after 2.3 h, which declined monoexponentially with a half-life of 5.6 h. The mean total body clearance was 37.6 l/h and the volume of distribution was 2921. The mean renal excretion (0–24 h) of the drug… CONTINUE READING
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