Pharmacokinetics of positron-labeled 1,3-bis(2-chloroethyl)nitrosourea in human brain tumors using positron emission tomography.

@article{Diksic1984PharmacokineticsOP,
  title={Pharmacokinetics of positron-labeled 1,3-bis(2-chloroethyl)nitrosourea in human brain tumors using positron emission tomography.},
  author={Mirko Diksic and Kazuhiro Sako and William Howard Feindel and Amami Kato and Yasunori Yamamoto and Simin Farrokhzad and Cynthia Carlton Thompson},
  journal={Cancer research},
  year={1984},
  volume={44 7},
  pages={3120-4}
}
The nitrosoureas are widely used in the chemotherapy of brain tumors, two of the most common being 1,3-bis(2-chloroethyl)nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. However, we do not understand how these compounds work, nor do we know which part of the molecule has antitumor activity. In six patients with brain tumor, we measured the kinetic behavior of positron-labeled 1,3-bis(2-chloroethyl)nitrosourea in both the tumor and the normal brain with the aid of positron emission… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Regional cerebralblood flow measurementand dynamic positron emissiontomography

  • Y. L. Yamamoto, E. Meyer, D. Menon, P. Roland, M. Diksic
  • CANCER RESEARCH VOL. 44 on April
  • 1984

Synthesis of ("C] labellednÃ-trosoureas

  • M. Diksic, S. Farrokhzad, Y. L. Yamamoto, W. Feindel
  • J. Radioanal.Chem., in press,
  • 1984
1 Excerpt

Comparisonof carmustine,procarbonin, and high-dosemethylpredisoloneas additions to surgery and radiotherapy for the treatment of malignant gliomas

  • S. B. Green, D. P. Byar, +16 authors T. A. Strike
  • CancerTreat. Rep.,
  • 1983
1 Excerpt

Metabolic and PharmacologieImagingof HumanGliomasby Positron EmissionTomography

  • W. Feindel, M. Diksic, L. Yamamoto, C. Thompson
  • 44th Annual Meeting of the American Association…
  • 1983
1 Excerpt

Pharmacokineticand metabolic studies in the human malignant glioma

  • Y. L. Yamamoto, M. Diksic, K. Sako, N. Arita, W. Feindel, C. J. Thompson
  • Radionuclidesand Brain Disease,
  • 1983
1 Excerpt

Similar Papers

Loading similar papers…