Pharmacokinetics of pioglitazone in lean and obese cats.

@article{Clark2012PharmacokineticsOP,
  title={Pharmacokinetics of pioglitazone in lean and obese cats.},
  author={Margaret H. Clark and Margarethe Hoenig and Duncan Craig Ferguson and Levent Dirikolu},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2012},
  volume={35 5},
  pages={
          428-36
        }
}
Pioglitazone is a thiazolidinedione insulin sensitizer that has shown efficacy in Type 2 diabetes and nonalcoholic fatty liver disease in humans. It may be useful for treatment of similar conditions in cats. The purpose of this study was to investigate the pharmacokinetics of pioglitazone in lean and obese cats, to provide a foundation for assessment of its effects on insulin sensitivity and lipid metabolism. Pioglitazone was administered intravenously (median 0.2 mg/kg) or orally (3 mg/kg) to… CONTINUE READING
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