Pharmacokinetics of phenylbutazone in neonatal foals.

  title={Pharmacokinetics of phenylbutazone in neonatal foals.},
  author={Jeff R. Wilcke and Mark Crisman and Richard A. Sams and Diane F. Gerken},
  journal={American journal of veterinary research},
  volume={54 12},
Single doses (2.2 mg/kg of body weight) of phenylbutazone (PBZ) were administered IV to 6 neonatal horses (5 to 17 hours old at time of dosing). Plasma concentrations of PBZ and its metabolite oxyphenbutazone were monitored serially for 120 hours after drug administration. Pharmacokinetic variables were calculated, using 1- and 2-compartment open models. Descriptive equations from the best model for each foal were then used to derive model-independent variables describing PBZ disposition… CONTINUE READING