Pharmacokinetics of parenteral and oral melperone in man

  title={Pharmacokinetics of parenteral and oral melperone in man},
  author={L. Borgstr{\"o}m and H. Larsson and L. Molander},
  journal={European Journal of Clinical Pharmacology},
SummaryThe pharmacokinetics of melperone (Buronil®, Ferrosan, Sweden) was studied after administration of various parenteral and oral doses to man. After parenteral administration, the data could be fitted to a two-compartment model, but after oral dosing the distribution phase could not be separated from the elimination phase, and so an one-compartment model gave the best fit. The half-lives were about 3–4 h, except after intramuscular injection, when the half-life was about 6 h. The… Expand
8 Citations
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A double-blind comparison of melperone and thiothixene in psychotic women using a new rating scale, the CPRS
A double-blind study of melperone and placebo in hospitalized chronic alcoholics in postintoxication phase.
Symbols in pharmacokinetics
  • M. Rowland, G. Tucker
  • Computer Science, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 2005
Ambulante Erfahrungen mit Melperon bei psychovegetativen Beschwerden unter kontrollierten Bedingungen
  • Therapiewoche
  • 1980
A clinical study of the effects of melperone and placebo on behavioural abnormalities in mentally retarded patients
  • Int Congr Int Assoc Sci Study of Mental Deficiency,
  • 1979