Pharmacokinetics of oxaliplatin in humans

@article{Ehrsson2002PharmacokineticsOO,
  title={Pharmacokinetics of oxaliplatin in humans},
  author={H. Ehrsson and I. Wallin and J. Yachnin},
  journal={Medical Oncology},
  year={2002},
  volume={19},
  pages={261-265}
}
Oxaliplatin is a novel platinum complex used for the treatment of metastatic colorectal carcinoma. The pharmacokinetics of the free fraction of oxaliplatin in blood were evaluated in 10 patients given 85 mg/m2 of oxaliplatin using an infusion time of 2 h. Blood samples were collected during and after the infusion and immediately placed on ice. The samples were ultrafiltrated centripetally and the concentration of oxaliplatin in the ultrafiltrate was determined by liquid chromatography in… Expand
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