Pharmacokinetics of orally administered furosemide
@article{Michael1974PharmacokineticsOO, title={Pharmacokinetics of orally administered furosemide}, author={Ronald Michael and Erik C. Ralph and W. Forrey Arden and M. Barbara}, journal={Clinical Pharmacology \& Therapeutics}, year={1974}, volume={15} }
Furosemide (80 mg) as tablets or aqueous solution was taken orally by normal subjects during a fast and postprandially. Comparative studies were obtained using intravenous furosemide and 35S‐furosemide. No significant differences were apparent between tablets and aqueous solution. During fasting, detectable drug levels appeared in the serum within 10 minutes, peaked (mean 2.2 μg/ml) between 60 and 70 minutes, and decreased to nearly undetectable levels between 3 and 4 hours after ingestion. The…
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The mean absorption times (MAT) for all oral doses were significantly longer than the MRTi.v.
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Inspection of plasma-time curves revealed secondary maxima in several subjects, suggesting enterohepatic cycling in healthy adult males, and urine data alone may be used to establish bioavailability of furosemide.
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From a statistical analysis of plasma levels of frusemide and amiloride, no significant differences between the reference drugs alone and the combination tablet were seen in peak plasma levels, mean times to peak or mean areas under the plasma concentration-time curves (AUCs).
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The results show that gestosis has only a marginal if any effect on the kinetics of furosemide in comparison with published kinetic parameters in healthy volunteers and patients with renal failure.
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Diuresis and urinary sodium excretion, 5 h after furosemide injection, were similar in both groups; larger potassium excretion was found in the cirrhotic patients.
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- MedicineEuropean Journal of Clinical Pharmacology
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Fractionation of labelled material in urine from two subjects demonstrated that approximately two thirds of the label recovered at 24 h had the same chromatographic properties as furosemide.
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The response to frusemide is determined by the concentration of drug in the tissue comparement, modified by factors controlling sodium homeostasis.
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