Pharmacokinetics of orally administered furosemide

@article{Michael1974PharmacokineticsOO,
  title={Pharmacokinetics of orally administered furosemide},
  author={Ronald Michael and Erik C. Ralph and W. Forrey Arden and M. Barbara},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1974},
  volume={15}
}
Furosemide (80 mg) as tablets or aqueous solution was taken orally by normal subjects during a fast and postprandially. Comparative studies were obtained using intravenous furosemide and 35S‐furosemide. No significant differences were apparent between tablets and aqueous solution. During fasting, detectable drug levels appeared in the serum within 10 minutes, peaked (mean 2.2 μg/ml) between 60 and 70 minutes, and decreased to nearly undetectable levels between 3 and 4 hours after ingestion. The… 
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TLDR
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TLDR
The results show that gestosis has only a marginal if any effect on the kinetics of furosemide in comparison with published kinetic parameters in healthy volunteers and patients with renal failure.
Pharmacokinetics of furosemide in patients with hepatic cirrhosis
TLDR
Diuresis and urinary sodium excretion, 5 h after furosemide injection, were similar in both groups; larger potassium excretion was found in the cirrhotic patients.
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TLDR
Fractionation of labelled material in urine from two subjects demonstrated that approximately two thirds of the label recovered at 24 h had the same chromatographic properties as furosemide.
Determinants of response to frusemide in normal subjects.
TLDR
The response to frusemide is determined by the concentration of drug in the tissue comparement, modified by factors controlling sodium homeostasis.
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