Pharmacokinetics of orally administered furosemide

@article{Michael1974PharmacokineticsOO,
  title={Pharmacokinetics of orally administered furosemide},
  author={Ronald Michael and Erik C. Ralph and W. Forrey Arden and M. Barbara},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1974},
  volume={15}
}
Furosemide (80 mg) as tablets or aqueous solution was taken orally by normal subjects during a fast and postprandially. Comparative studies were obtained using intravenous furosemide and 35S‐furosemide. No significant differences were apparent between tablets and aqueous solution. During fasting, detectable drug levels appeared in the serum within 10 minutes, peaked (mean 2.2 μg/ml) between 60 and 70 minutes, and decreased to nearly undetectable levels between 3 and 4 hours after ingestion. The… 

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TLDR
There was free water clearance during peak diuresis in all subjects, suggesting that furosemide does not affect the diluting segment of the nephron, and a greater rate of nonrenal elimination than in normal subjects.

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