Pharmacokinetics of oral omeprazole in llamas.

  title={Pharmacokinetics of oral omeprazole in llamas.},
  author={K P Poulsen and Geoffrey W. Smith and Jennifer L Davis and Mark G Papich},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={28 6},
Gastrogard, an oral formulation of omeprazole, was given to six llamas at a dose of 4 mg/kg once a day for 6 days. Plasma samples were collected at 0, 15, 30, 45, and 60 min and 2, 3, 4, 6, 8, 12, and 24 h on days 1 and 6. Plasma omeprazole concentrations were measured by high-pressure liquid chromatography with ultraviolet detection. Pharmacokinetic parameters calculated included the area under the curve (AUC(0-infinity)), peak plasma concentration (Cmax), time of peak plasma concentration… CONTINUE READING

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