Pharmacokinetics of oral methotrexate in children.

  title={Pharmacokinetics of oral methotrexate in children.},
  author={Frank M Balis and J L Savitch and W. Archie Bleyer},
  journal={Cancer research},
  volume={43 5},
The absorption and disposition kinetics of p.o. methotrexate were studied in 15 children. Serum levels and urinary excretion of methotrexate, as measured by the dihydrofolate reductase inhibition assay, were monitored following a routine p.o. dose (6.3 to 28.1 mg/sq m) administered after an overnight fast. Significant interindividual variability was noted in peak levels (range, 0.27 to 1.1 microM), time to peak (1 to 5 hr), area under the serum concentration-time curve (1.08 to 5.00 microM . hr… CONTINUE READING

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